is a never ending story

1 cup of walnuts a day might increase coronary heart well being by way of the intestine

1 cup of walnuts a day might increase coronary heart well being by way of the intestine

walnuts on blue plate next to nutcracker on wooden tableShare on Pinterest
One cup of walnuts a day might assist hold the guts wholesome, however why? Picture credit score: Ingrid Bertens/Stocksy.
  • Since walnuts have coronary heart well being advantages, researchers from Texas Tech College and Juniata Faculty carried out a research to research what impression they’ve on the intestine microbiome.
  • The researchers have been curious whether or not it’s attainable that the guts advantages derived from walnuts begin within the intestine.
  • The researchers assigned diets to a few teams of individuals, together with one group that ate complete walnuts, after which examined organic samples from every participant.
  • Their findings confirmed that individuals who consumed the weight-reduction plan with walnuts had increased ranges of the amino acid L-homoarginine of their guts.
  • Since folks with decrease ranges of homoarginine are at the next danger for heart problems, this discovering confirmed that it is perhaps attainable to enhance coronary heart well being by making dietary modifications that have an effect on the intestine.

Whereas scientists know that sure meals enhance coronary heart well being, there are numerous questions remaining, akin to how this occurs, and what different meals exist which will decrease cardiovascular danger.

Researchers from Texas Tech College in Lubbock and Juniata Faculty in Huntingdon, PA, wished to study extra about how walnuts might profit the guts, and whether or not that begins within the intestine.

They carried out their research by analyzing the genetic expression of microbes in members who both did or didn’t eat a weight-reduction plan with walnuts.

The research outcomes have been offered at Uncover DMB, which is the annual assembly of the American Society of Biochemistry and Molecular Biology.

In response to the Facilities for Illness Management and Prevention (CDC), coronary heart illness is the main reason behind loss of life in adults in the US. Almost 700,000 folks die from coronary heart illness every year.

Many elements affect coronary heart well being, and an essential one is vitamin. Individuals who observe diets which can be excessive in fats and ldl cholesterol usually tend to develop circumstances that may finally result in coronary heart illness.

To assist scale back the danger of coronary heart illness, folks can select diets which can be low in fats, characteristic lean meats, and are low in sugar and salt. Avoiding processed meals or meals excessive in trans fat may help as nicely.

Some heart-healthy meals the Nationwide Institutes of Well being (NIH) suggest folks eat embody:

  • greens
  • fruits
  • complete grains
  • fish and lean meats
  • nuts.

Latest analysis exhibits that walnuts, specifically, can enhance an individual’s heart problems danger profile.

A wholesome intestine microbiome is crucial to good well being. The intestine microbiota is a bunch of microorganisms that colonize the gastrointestinal tract. Some estimates recommend that there are 1,013 micro organism within the human gastrointestinal tract, about as many as human cells within the physique.

Typically sickness or life-style selections could cause modifications to the intestine microbiome and make dangerous micro organism outweigh good micro organism.

The NIH word that “[t]he intestine microbiome performs an essential function in human well being and influences the event of continual illnesses starting from metabolic illness to gastrointestinal issues and colorectal most cancers.”

There are methods to enhance intestine well being, akin to taking probiotic dietary supplements to rebalance the intestine microbiome. Meals folks can eat to assist with this embody yogurt, pickled greens, and kombucha tea.

The researchers who carried out the present research have been occupied with how walnuts impression intestine well being and enhance coronary heart well being.

Walnuts have the next alpha-linolenic acid (ALA) content material, which is critical as a result of ALA might impression neurological and cardiovascular well being.

The researchers analyzed information from 42 members for this research. The members all had an elevated danger for heart problems.

All members initially adopted a conventional Western weight-reduction plan for two weeks. In response to the researchers, their dietary breakdown included a 50% carbohydrate consumption, 16% protein, and 34% fat.

The scientists took stool samples to research the members’ intestine microbiomes, after which positioned the members in one among three teams.

The primary group, which was referred to as the “walnut weight-reduction plan group”, consisted of members who ate 57–99 grams (g.) of walnuts per day — roughly 1 cup of walnuts.

The second group consumed the identical quantities of omega-3 fatty acid alpha-linolenic acid current in walnuts with out consuming walnuts. This was the “matched walnut management weight-reduction plan.

The third group was assigned to complement ALA with oleic acid — whereas not consuming walnuts — and was known as the “oleic acid replaces ALA in weight-reduction plan with out walnuts” group.

On the finish of the 6-week weight-reduction plan durations, the researchers collected stool samples from the members and analyzed the samples with metatranscriptomics “to research the intestine microbiota composition and performance.”

After gathering stool samples, the researchers carried out a genetic evaluation of the intestine microbiota from every group. They have been in a position to decide whether or not there have been increased or decrease ranges of sure micro organism.

The researchers discovered increased ranges of Gordonibacter micro organism within the walnut weight-reduction plan group. This bacterium is chargeable for metabolizing plant compounds.

The researchers additionally noticed increased ranges of gene expression in pathways concerned with the amino acid L-homoarginine within the walnut weight-reduction plan group.

That is vital as a result of folks with low homoarginine ranges are at the next danger for coronary heart illness.

Moreover, they discovered that the members noticed enhancements of their dysbiosis index values — the ratio of dangerous micro organism to good micro organism — after spending 6 weeks on their diets.

Whereas the participant pool for the research was small, the outcomes recommend the potential of enhancing one’s danger for heart problems by making dietary modifications that impression the intestine.

Mansi Chandra, an undergraduate researcher at Juniata Faculty who will current the research, commented on it in an interview with Medical Information As we speak.

“The character of the research itself may be very distinctive […] to our data, [as] metatranscriptomics has not been used beforehand to evaluate the impact of walnut consumption on intestine microbiota gene expression and is the primary of its sort,” mentioned Chandra.

“The findings of those exploratory analyses contribute to additional understanding of walnut-related modulation of intestine microbiome, which may very well be very impactful in studying how intestine well being impacts our coronary heart well being usually.”

– Mansi Chandra

Dr. John Higgins, a professor of cardiovascular medication with McGovern Medical College at UTHealth Houston, who was not concerned within the research, spoke with MNT in regards to the findings.

“Walnuts are a wealthy supply of omega-3 fatty acids, particularly alpha-linolenic acid, and are helpful for enhancing cardiovascular well being. They scale back irritation, enhance ldl cholesterol stability, scale back blood strain, and scale back danger of metabolic syndrome and heart problems,” Dr. Higgins identified.

When requested in regards to the significance of such analysis, Dr. Higgins mentioned it highlights “how completely different organ techniques are interconnected.”

“On this case, the gastrointestinal system and the guts [are interconnected],” famous Dr. Higgins. “A wholesome intestine means a wholesome coronary heart!”

“This analysis means that by adjusting weight-reduction plan and modulating intestinal microbiota composition and metabolism — e.g. beginning to eat a cup of walnuts every day — we could possibly higher assist heart problems prevention,” he additional commented, although he cautioned that “[m]ore analysis is required.”

Dr. Ernst von Schwarz, a heart specialist and professor at UCLA, not concerned on this research, additionally spoke with MNT in regards to the analysis.

In response to him, “[t]he research additionally helps the thought […] to advertise the idea of a Mediterranean-type weight-reduction plan as essentially the most heart-healthy weight-reduction plan, which in some research even has [been] proven to lead to a regression of atherosclerosis (calcification/hardening) of the blood vessels within the coronary heart, the mind, and even within the sexual organs.”

“Although we’re conscious of the long-term advantages of a Mediterranean weight-reduction plan, we have no idea the precise mechanisms,” Dr. von Schwarz continued. “Due to this fact, this research — amongst others — helps us to grasp attainable biochemical pathways which can be affected by dietary elements, together with walnuts.”